6293-83-0, name is 2-Iodo-4-nitroaniline, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C6H5IN2O2
General procedure: A mixture of compound2 (1.0 equiv), 10% Pd/C (0.016 equiv), PPh3 (0.125 equiv), CuI (0.02 equiv), and triethylamine (2 equiv) in ethanol (5 mL) was stirred at 25-30 C for 30 min under nitrogen. To this was added iodoarene (3) (1.0 equiv), and the mixture was initially stirred at room temperature for 1 h and then at 70 C for the time indicated in Table 2. After completion of the reaction, the mixture was cooled to room temperature, diluted with EtOAc (50 mL), and filtered through Celite.The organic layers were collected, combined, washed with water (3 30 mL),dried over anhydrous Na2SO4, filtered, and concentrated under low vacuum.The crude residue was purified by column chromatography on silica gel using methanol/dichloromethane to afford the desired product.
The synthetic route of 6293-83-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Babu, P. Vijaya; Gorja, Dhilli Rao; Meda, Chandana Lakshmi T.; Deora, Girdhar Singh; Kolli, Sunder Kumar; Parsa, Kishore V.L.; Mukkanti; Pal, Manojit; Tetrahedron Letters; vol. 55; 20; (2014); p. 3176 – 3180;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com