In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 766-99-4, name is 1-Ethynyl-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: iodides-buliding-blocks
General procedure: An oven-dried Schlenk reaction tube equipped with a magnetic stirrer bar and a Teflon stopcock was evacuated while hot and allowed to cool under N2. The tube was first charged with CuI (0.02 mmol), TMEDA (0.05 mmol), and benzoyl chloride (1.2 mmol), follow byphenylacetylene (1 mmol) and Et3N (3.0 mmol). The mixture wasthen stirred at r.t. for 1 h under N2. When the reaction was complete, sat. aq NaHCO 3 (5 mL) and EtOAc (20 mL) were added. The reaction system was allowed to partition, and the organic phase was dried with Na2SO4, filtered, and concentrated on a rotary evaporator. The residue was purified by chromatography (silica gel) to give the cross-coupling product 3a (185.4 mg, 90%) as a white solid.
The synthetic route of 766-99-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yin, Weiyan; He, Haifeng; Zhang, Yani; Luo, Di; He, Hongwu; Synthesis; vol. 46; 19; (2014); p. 2617 – 2621;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com