Electric Literature of 83027-73-0, These common heterocyclic compound, 83027-73-0, name is 5-Bromo-1-chloro-3-fluoro-2-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dry methanol (160ml_) was cooled to 10 C and potassium hydroxide (14.9g) was added portionwise over 25 minutes. Once dissolved, this solution was added over 15 minutes to a refluxing solution of 5-bromo-1-chloro-3-fluoro-2-iodo-benzene (CAS Reg. No. 83027-73-0, 40.0 g) in dry methanol (320ml_). After 46 hours refluxing the reaction mixture was concentrated and partitioned between water (500ml_) and ethyl acetate (500ml_). The aqueous phase was extracted with further ethyl acetate (2 x 200ml_). The combined organic layers were washed with brine (400ml_), dried over magnesium sulfate, concentrated and purified by chromatography on silica eluting with ethyl acetate in iso-hexane to give 5-bromo- 1 -chloro-2-iodo-3-methoxy-benzene (37.767g) as a pale pink solid. 1H NMR (500 MHz, CDCI3) delta (delta) 7.28 (d, 1 H), 6.82 (d, 1 H), 3.90 (s, 3H)
The synthetic route of 83027-73-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA LIMITED; HACHISU, Shuji; SCUTT, James Nicholas; WILLETTS, Nigel James; WO2015/32702; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com