These common heterocyclic compound, 141738-80-9, name is 3-Chloro-4-iodobenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H3ClF3I
A mixture of 0.5 g (1.6 mmol) of 3-chloro-4-iodobenzotrifluoride 0.7 g (3.8 mmol), N- Boc-piperazine, 41 mg (0.04 mmol) Tris (dibenzylideneacetone) dipalladium chloroform complex, 0.44 g (4.43 mmol) SODIUM-T-BUTOXIDE and 48 mg (0.16 mmol) tri-o- tolylphosphine in 6 ml dioxane was heated overnight at 100 C. The solution was allowed to cool to room temperature, taken up in ether (30ML) and washed with brine (25ML). The organic layer was dried over NA2SO4, filtered and the solvent was removed in vacuo. The crude oil was chromatographed over on silica gel: Eluent: Heptane-AcOEt 0-10% over 15MIN to provide the title compound (0.06g, 10%) as a brown oil, MS (m/e): 365.1 (MH+, 100%).
The synthetic route of 3-Chloro-4-iodobenzotrifluoride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/23260; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com