Synthetic Route of 914636-93-4, A common heterocyclic compound, 914636-93-4, name is 3-Fluoro-5-iodobenzaldehyde, molecular formula is C7H4FIO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Fluoro-5-iodobenzaldehyde, monomethyl malonate, and a catalytic amount of pyrrolidine are heated in pyridine. After cooling, the solvent is distilled off in vacuo. 2N HCl and ethyl acetate are added to the residue, and the phases are separated. The organic layer is washed with brine and dried over Na2SO4. After evaporation, the residue is purified by CC on silica gel with EtOAc/hexane. Evaporation of appropriate fractions yields the title compound.
The synthetic route of 914636-93-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PSYCHOGENICS, INCstatuts; CHANDRASEKHAR, Jayaraman; KOZIKOWSKI, Alan, P.; LIU, Jianhua; TUECKMANTEL, Werner; WALKER, Joel, R.; YUEN, Po-wai; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; WO2010/45212; (2010); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com