Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 141738-80-9, name is 3-Chloro-4-iodobenzotrifluoride, A new synthetic method of this compound is introduced below., Product Details of 141738-80-9
Stef> 1; A stirring mixture of 3-(3-(4-bromophenyl)propyl)-4-(2-fluorophenyl)-lH-l,2,4-triazol- 5(4H)-one (0.200 g, 0.53 mmol, Example 29, step 3), copper(I) iodide (0.010 g, 0.053 mmol), potassium carbonate (0.147 g, 1.06 mmol), L-proline (0.012 g, 0.106 mmol) and DMSO (5 mL) was sub-surface purged with nitrogen gas for 10 minutes before adding 2-chloro-4-trifluoromethyliodobenzene (0.103 mL, 0.58 mmol). The reaction vessel was stirred at 90 C for 48 h, cooled to RT, and diluted with ether and brine. The organic extract was washed sequentially with IN HQ (aq.) and water. The organic layer was then concentrated in vacuo. The resulting crude material was purified on silica gel eluting with a solvent gradient of 0% to 45% EtOAc in hexanes to afford 3-(3-(4-bromophenyl)propyl)-4-(2-fluorophenyl)-l-(2-chloro-4- (trifluoromethyl)phenyl) – 1 H- 1 ,2,4 -triazol-5 (4H) -one .
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; INCEPTION 2, INC.; STOCK, Nicholas, Simon; CHEN, Austin, Chih-Yu; BRAVO, Yalda, Mostofi; JACINTHO, Jason, Duarte; WO2015/35059; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com