Related Products of 459424-72-7,Some common heterocyclic compound, 459424-72-7, name is 1,2,3-Trifluoro-4-iodobenzene, molecular formula is C6H2F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: In a 25 mL reaction tube, Mn(OAc)3.2H2O(10 mol%), DABCO (2.5 equiv.) and a stirring bar were added. Then iodobenzene(1 mmol), phenyl acetylene (1 mmol) and PEG-400 were injected by syringe. The reaction tube was closed and transferred to a 70 C oil bath for 19-24 hours. After the reaction completed, cool down the reaction mixture to room temperature. Water (2 mL) was added and the reaction mixture was extracted with ethyl acetate and then concentrated and purified by column chromatography.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2,3-Trifluoro-4-iodobenzene, its application will become more common.
Reference:
Article; Qi, Xinxin; Jiang, Li-Bing; Wu, Xiao-Feng; Tetrahedron Letters; vol. 57; 15; (2016); p. 1706 – 1710;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com