Synthetic Route of 249647-25-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 249647-25-4, name is 3-Bromo-4-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows.
Method 13: Synthesis of 5-(5-{2-r5-(3-bromo-4-iodophenyl)-l,2,4-oxadiazol-3-yll-3- meth lbutan-2-yl}pyridin-2-yl)pyrimidin-2-amine (Example 69)A suspension of R19 (163.3 mg, 0.50 mmol) and Iota,Gamma-carbonyldiimidazole (81.0 mg, 0.50 mmol) in THF (2.0 mL) is heated at 50C for 30 min. 1-8.4 (100.0 mg, 0.33 mmol) is added and the solution is heated under reflux for 3 hours. The mixture is cooled to room temperature and AcOH (0.2 mL) is added. The reaction mixture is stirred at 80C overnight. After cooling to room temperature, the mixture is poured into water and extracted with EtOAc. The organic layers are combined, dried over anhydrous Na2S04 and filtered. The solvent is removed under reduced pressure. Purification via silica gel column chromatography affords Example 69 (67.0 mg).
The chemical industry reduces the impact on the environment during synthesis 3-Bromo-4-iodobenzoic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; HUBER, John, D.; LIU, Weimin; LO, Ho Yin; LOKE, Pui Leng; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee, M.; WO2012/40137; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com