Application of 1027513-14-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1027513-14-9, name is 1-Fluoro-3-iodo-5-(trifluoromethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
10284] The reaction was carried out according to Scheme1, Step-5, using tert-butyl (Z)-(2-(4-(i-(3-fluoro-i-(tetra-hydro-2H-pyran-2-yl)- 1 H-indazol-5-yl)-2-(4,4,5,5-tetram-ethyl-i ,3,2-dioxaborolan-2-yl)but-i -en-i -yl)-phenoxy) ethyl)carbamate (950 mg, 1.8 mmol) for compound 208 and 1 -fluoro-3-iodo-5-(trifluoromethyl)benzene (523 mg, 1.8 mmol) for compound 209. The crude product was purified by silica gel chromatography (2:8 EtOAc in n-hexane) to give the title compound of Ex. 3, Step-4 (0.5 g, 4 1%).
The synthetic route of 1-Fluoro-3-iodo-5-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eisai R&D Management Co., Ltd.; BOCK, Mark; HAO, Ming-Hong; KORPAL, Manav; NYAVANANDI, Vijay Kumar; PUYANG, Xiaoling; SAMAJDAR, Susanta; SMITH, Peter Gerard; WANG, John; ZHENG, Guo Zhu; ZHU, Ping; (141 pag.)US2016/347717; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com