In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59382-39-7, name is 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H3F4I
Dissolve 1-fluoro-4-iodo-2-trifluoromethylbenzene (813 mg, 2. 8 mmol) in triethylamine (6 mL). Add 3-ethynyl-5-methoxypyridine, (prepared as described in PREPARATION 10), (400 mg, 3. 0 mmol) followed by bis (triphenylphosphine) palladium (II) dichloride (0. 100 g, 0. 14 mmol) and copper (I) iodide (53 mg, 0. 28 mmol). Heat at 70 C for 16 h, concentrate, and purify using silica gel chromatography, eluting with 100 : 0 to 90 : 10 methylene chloride : ethyl acetate, to give the title compound as a pale yellow solid (820 mg, 99%). 1HNMR (300 MHz, CDCl3) 6 3. 89 (s, 3H), 7. 19-7. 26 (m, 1H), 7. 30-7. 31 (m, 1H), 7. 69- 7. 74 (m, 1H), 7. 79-7. 82 (m, 1H), 8. 30 (d, J = 2. 8 Hz, 1H), 8. 38 (d, J = 1. 3 Hz, 1H) ; MS (APCI) : m/z = 296 [M+H] +.
The synthetic route of 59382-39-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com