Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 229178-74-9, name is 2,6-Difluoro-3-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H3F2IO2
To a mixture of 2,6-difluoro-3-iodobenzoic acid 3 (2.84 g, 10.0 mmol) in methanol (30 mL) was added SOCl2 (0.1 mL) dropwise at 0 C. After being stirred at reflux for 3 h, the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate 15:1 to 10:1, v/v) to give the desired compound 4 as a white solid (2.75 g, 92%): mp 54-55 C (lit.6 mp 53-55 C); 1H NMR (CDCl3) delta 3.95 (s, 3H, CH3), 6.78-6.82 (t, 1H, J = 8.4 Hz, ArH), 7.78-7.83 (m, 1H, ArH); 13C NMR (CDCl3) delta 53.10, 75.42, 75.46, 75.69, 75.73 (dd, JC-F = 4.2, inlMMLBox = 26.8 Hz), 111.49, 111.69, 111.89 (t, JC-F = 19.8 Hz), 113.81, 113.84, 114.03, 114.07 (dd, JC-F = 3.9, inlMMLBox = 22.4 Hz), 141.42, 141.45, 141.51, 141.54 (dd, JC-F = 3.1, inlMMLBox = 9.4 Hz), 157.99, 158.05, 160.52, 160.58 (dd, JC-F = 6.2, inlMMLBox = 252.6 Hz), 159.48, 159.53, 162.04, 162.09 (dd, JC-F = 5.1, inlMMLBox = 256.2 Hz), 161.16; GC-MS: 298 M+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 229178-74-9.
Reference:
Article; He, Qiu-Qin; Gu, Shuang-Xi; Liu, Jia; Wu, Hai-Qiu; Zhang, Xuan; Yang, Liu-Meng; Zheng, Yong-Tang; Chen, Fen-Er; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 5039 – 5045;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com