Adding a certain compound to certain chemical reactions, such as: 261903-03-1, name is 2-Bromo-4-iodobenzaldehyde, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 261903-03-1, Recommanded Product: 2-Bromo-4-iodobenzaldehyde
Example 91; Lambda/-hydroxy-6-[4-(pyridin-3-ylethynyl)phenyl]isoquinoline-8-carboxamide; A. Lambda/-[(Z)-(2-bromo-4-iodophenyl)methylidene]-2,2-dimethoxyethanamine; To a solution of 2-bromo 4-iodobenzaldehyde (5.0 g, 16.1 mmol) in dry toluene (50 mL) was added aminoacetaldehyde dimethyl acetal (3.5 mL, 32.2 mmol) at room temperature. The reaction mixture was refluxed under Dean-Stark trap for 18 h. The solvent was evaporated under reduced pressure to obtain the title compound (6.2 g, crude) as an off-white solid. LC-MS: [M, M+2]+ 399.7 Mass: calculated for CnHi3BrINO2, 398.04 1H NMR (400 MHz, delta ppm, CDCl3): delta 8.56 (s, IH), 7.94 (d, IH), 7.74 (d, IH), 7.67 (m, IH), 4.68 (t, IH), 3.81 (d, 2H), 3.42 (s, 6H).
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Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENENATO, Kerry, Ellen; CHOY, Allison, Laura; HALE, Michael, Robin; HILL, Pamela; MARONE, Valerie; MILLER, Matthew; WO2010/100475; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com