Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13101-40-1, name is 1-Bromo-3-chloro-5-iodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-3-chloro-5-iodobenzene
In a 250mL three-necked flask, nitrogen is introduced.Add 0.02molRaw material I, 150ml DMF, 0.022mol raw material II,0.0002 mol of palladium acetate, stirred,Then add 3mL of 0.01mol/mL K3PO4 aqueous solution,The reaction was heated under reflux at 150 C for 12 hours.Sampling the plate and the reaction is complete.Cool naturally, add 100mL water,The mixture was filtered and the filter cake was dried in a vacuum oven.The residue obtained was purified by silica gel column to giveRaw material A-1;
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Lu Ying; Wang Fang; Xie Dandan; Wu Xiuqin; Zhang Zhaochao; (39 pag.)CN109928911; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com