Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 42048-11-3, name is 2-Chloro-6-iodotoluene, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks
A solution of a (1.8 g, 6 8 mmol, 1.0 eq), b (1 0 g, 7.5 mmol, 1 1 eq), KOAc (2 0 g, 20.4 mmol, 3.0 eq), copper powder (132.0 mg, 2 0 mmol, 0.3 eq), and CuiOAc)?. (364.0 mg, 2.0 mmol, 0.3 eq) in 2-pentanol (50.0 mL) was stirred at 140 C overnight under N?. atmosphere, then cooled to room temperature. The mixture was filtered and the filtrate was concentrated to give crude e (2 2 g, ca.100%) LC/MS: 262.0
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SILICON SWAT, INC.; CHAMBERLAIN, Brian T.; RICE, James M.; JERNIGAN, Finith E., III; SHERMAN, Woody; KULKARNI, Meghana M.; SHECHTER, Sharon; ALLEN, Bryce K.; TAN, Dazhi; MARINO, Kristen A.; LIN, Zhixiong; (292 pag.)WO2019/100061; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com