Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 180624-08-2, name is 4-Bromo-2-iodo-6-nitroaniline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H4BrIN2O2
4-bromo-2-iodo-6-nitroaniline (150 mg, 0.44 mmol) and 3,5-Dimethylisoxazole-4-boronic acid pinacol ester (390 g, 1.75 mmol) was added to a solvent mixture of 1,2-dimethoxyethane (2 ml) and water (1 ml). To the above mixture were added PEPPSI-Ipr (30 mg, 0.04 mmol) and Cs2CO3 (0.86 g, 2.64 mmol). The reaction mixture was heated at 120 C. in microwave reactor for 2 hs. The reaction mixture was then diluted with EtOAc (100 ml), washed with bring (50 ml, 2 times). The organic solvent was evaporated and the residue was dissolved in DCM and purified with combi-flash column chromatography (product came out at 25% MeOH/DCM) to afford 2,4-bis(3,5-dimethylisoxazol-4-yl)-6-nitroaniline. C16H16N4O4. 329.2 (M+1)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 180624-08-2.
Reference:
Patent; Gilead Sciences, Inc.; Aktoudianakis, Evangelos; Chin, Gregory; Corkey, Britton Kenneth; Du, Jinfa; Elbel, Kristyna; Jiang, Robert H.; Kobayashi, Tetsuya; Lee, Rick; Martinez, Ruben; Metobo, Samuel E.; Mish, Michael; Munoz, Manuel; Shevick, Sophie; Sperandio, David; Yang, Hai; Zablocki, Jeff; US2014/336190; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com