Related Products of 74128-84-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74128-84-0, name is 2-Bromo-1-iodo-3-methoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2-bromo-1-iodo-3-methoxybenzene (0.88 g, 2.81 mmol) obtained in Step B was dissolved in DCM (4 mL) andcooled to 0-5C. 1M BBr3 (8.4 mL, 8.43 mmol) was slowly added dropwise thereto, and the mixture was stirred at 0-5Cfor 1 hour and additionally stirred at room temperature for 1 hour. After termination of the reaction, the reaction solutionwas cooled to -20C and diluted by slowly adding methanol. The mixture was stirred at room temperature for 30 minutes.After addition of saturated NaHCO3 aqueous solution, the reaction solution was extracted with DCM. The organic layerwas dried with anhydrous magnesiumsulfate, concentrated under reduced pressure and purified by column chromatography(eluent, EtOAc/Hex = 1/5) to obtain the title compound (0.723 g, 86%).1H NMR (500 MHz, CDCl3) delta 7.43-7.39(m, 1H), 7.02-6.92 (m, 2H), 5.61 (s, 1H)
The synthetic route of 2-Bromo-1-iodo-3-methoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem, Ltd.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; PAEK, Seung Yup; KANG, Seung Wan; KIM, Byung Gyu; LEE, Chang Seok; KIM, Sung Wook; LEE, Sang Dae; (369 pag.)EP3239143; (2017); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com