Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59382-39-7, name is 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., name: 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene
Sequentially add 3-chloro-5-ethynylpyridine, (prepared as described in PREPARATION 27), (300 mg, 2. 2 mmol), (bis (triphenylphosphine) palladium (II) dichloride (69 mg, 0. 10 mmol), and copper (I) iodide (38 mg, 0. 198 mmol) to a solution of 1-fluoro-4-iodo-2-trifluoromethylbenzene (575 mg, 1. 98 mmol) in triethylamine (4 mL) under nitrogen. Heat at 70 C for 2. 5 h and concentrate. Purify the residue by silica gel chromatography, eluting from 0 : 100 to 20 : 80 using ethyl acetate : hexanes, to give the title compound as a white solid (520 mg, 88%). 1HNMR (300 MHz, CDCl3) 8 7. 19-7. 23 (m, 1H), 7. 67-7. 74 (m, 1H), 7. 79-7. 87 (m, 2H), 8. 55 (d, J = 2. 3 Hz, 1H), 8. 63 (d, J = 1. 7 Hz, 1H) ; MS (APCI) m/z= 300 [M+H] +.
The synthetic route of 59382-39-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com