Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1252046-13-1, name is 2-Bromo-5-iodobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-Bromo-5-iodobenzonitrile
Under an argon atmosphere, to a 500 ml, three-neck flask, 5.00 g of (6-bromopyridin-3-yl)boronic acid, 7.63 g of 2-bromo-5-iodobenzonitrile, 0.28 g of Pd(OAc)2, 1.02 g of SPhos, and 10.52 g of K3PO4 were dissolved in 120 ml of a deaerated mixture solvent of toluene/ethanol/water (10:1:2), followed by stirring at about 80 C. for about 12 hours. After finishing the reaction, water was added, and extraction with CH2Cl2 was conducted. An organic layer was separated and dried with MgSO4, and solvents were removed by distillation under a reduced pressure. The crude product thus obtained was separated by silica gel column chromatography to obtain 6.20 g (yield 74%) of Intermediate O. The molecular weight of Intermediate O measured by FAB-MS was 338.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1252046-13-1.
Reference:
Patent; Samsung Display Co., Ltd.; SAKAMOTO, Naoya; (128 pag.)US2019/296247; (2019); A1;,
Iodide – Wikipedia,
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