These common heterocyclic compound, 7212-28-4, name is 2-Iodo-N-phenylacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks
EXAMPLE 146 Trans-2-carboxy-5,7-dichloro-4-(phenylaminocarbonylmethylamino)-1,2,3,4 -tetrahydroquinoline hydrochloride This material was prepared by the method given in Example 145 step a and b) using phenylaminocarbonylmethyliodide in place of benzyl bromide to yield the title compound as colourless crystals, m.p. 163-164.2 C. dec.; delta (360 MHz, DMSO) 1.93 (1H, ddd, J=13.3, 12.2 and 3.8 Hz, CHA CHB HC CHD), 2.73 (1H, dm, J=13.3 Hz, CHA CHB HC CHD), 4.00 (2H, 2d, J=16.2 Hz, NHCH2 CONHPh), 4.32 (1H, dd, J=12.2 and 3.8 Hz, CHA CHB HC CHD), 4.78 (1H, bs, CHA CHB HC CHD), 6.73 (1H, d, J=2.0 Hz, 6-H or 8-H), 6.92 (1H, d, J=2.0 Hz, 6-H or 8-H), 7.10 (1H, m, ArH), 7.18 (1H, s, ArNH), 7.35 (2H, m, 2 ArH), 7.60 (2H, m, 2 ArH), 9.5 (2H, bm, NH2), 10.72 (1H, m, CHD NHCH2). m/e (FAB+) 394 (M+1). Found C, 46.73; H, 4.28; N, 8.75; C18 H17 Cl2 N3 O3.1.9HCl requires C, 46.50; H, 4.32; N, 9.05%.
The synthetic route of 2-Iodo-N-phenylacetamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme, Ltd.; US5231102; (1993); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com