Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 136618-42-3, name is Benzyl 4-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 136618-42-3
General procedure: To a DMF solution (10 mL) of benzyl iodobenzoate (100 mg, 4 mmol), tetrabutylammonium chloride (1.7 g), NaHCO3(0.9 g, 11 mmol) and palladium acetate (80 mg) at 0C, a solution of allyl alcohol (0.41 mL, 6 mmol) in DMF (2 mL) was added. The reaction mixture wasallowed to warm slowly to room temperature, heated at 50Cfor 2 h, diluted with 3N HCl (50 mL), and extracted with EtOAc (5 × 15 mL).The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The product containing1h-1or1r-1was used as such for the next reaction.To a solution of (2-carboxyethyl) triphenylphosphonium bromide (4 mmol) in THF (30 mL), a solution of 2 M lithium bis(trimethylsilyl)amide (LHMDS) (10 mmol, 5 mL THF) was slowly added under nitrogen atmosphere at -78C. The reaction mixture was stirred at -78C for 15 mins, and allowed to warm slowly to 0C for 0.5 h. After being stirred at 0C for 1 h, a solution of appropriate1h-1or1r-1in THF (2 mL) was slowly added at -78C. The reaction mixture was allowed to warm slowly to 0C and stirred at the same temperature for 18 h. The reaction was quenched with 30 mL aqueous 4 M HCl and extracted with EtOAc (3 × 15 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel to afford the mixture of isomers1h-2and1r-2.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 136618-42-3.