Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 481075-59-6, name is 1-Bromo-3-iodo-5-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Bromo-3-iodo-5-(trifluoromethyl)benzene
Step 1: To a solution of 1-bromo-3-iodo-5-(trifluoromethyl)benzene (55) (2.0 g, 5.7 mmol), thiobenzoic acid (56), (0.67 ml, 5.7 mmol), 1,10-phenanthroline (0.21 g, 1.08 mmol) in toluene were added DIPEA (2 ml) and CuI (0.11 g, 0.57 mmol). The resulting mixture was degassed by bubbling argon for 2 min and stirred at 110 C. for 24 hrs under argon. The reaction mixture was filtered through Celite and concentrated under reduced pressure. Purification by flash chromatography (5% to 15% EtOAc hexanes gradient) gave benzothioate 57 as a light yellow oil. Yield (1.7 g, 82%); 1H NMR (400 MHz, CD3OD) delta 7.96-8.04 (m, 4H), 7.80-7.83 (m, 1H), 7.69 (tt, J=6.0, 1.6 Hz, 1H), 7.53-7.58 (m, 2H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 481075-59-6.