These common heterocyclic compound, 141738-80-9, name is 3-Chloro-4-iodobenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 141738-80-9
General procedure: To a mixture of the respective halide (0.979 mmol), Pd(dba)2 (0.049 mmol) and Q-Phos (0.049 mmol) in 2.5 mL THF were added 2.15 mL of 2-tBu-oxy-2-oxoethylzinc chloride (0.5M solution in Et20). The reaction mixture was flushed with argon and then heated to 70C for 6 h. After concentration of the solvent in vacuo the residue was dissolved in EtOAc and extracted with water and brine. The organic layer was dried over MgS04, concentrated in vacuo and purified by CC using Hept/EtOAc to give the desired ester derivatives. 2-Chloro-4-(trifluoromethyl)phenylacetic acid tBu-ester
The synthetic route of 3-Chloro-4-iodobenzotrifluoride has been constantly updated, and we look forward to future research findings.