Sources of common compounds: 133232-56-1

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Adding a certain compound to certain chemical reactions, such as: 133232-56-1, name is 3-Iodo-2-methylbenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133232-56-1, Computed Properties of C8H7IO2

To a solution of compound 2 (63.0 g, 0.24 mol) in MeOH (300 mL) was added dropwise a freshly prepared solution of SOCI2 (52 mL, 0.72 mol) in MeOH (100 mL) at 0 0C. The mixture was heated to reflux for 3 hours. TLC (petroleum ether: ethyl acetate = 10:1) showed the reaction was complete, then the mixture was concentrated in vacuo. The residue was purified by column chromatography (petroleum ether) to afford compound 3 (60 g, 92%) as brown oil. 1H NMR (400 MHz, CDCI3): delta 7.94-7.96 (d, J = 8.0 Hz, 1 H), 7.71-7.73 (d, J = 8.0 HzJ H), 6.87- 6.91 (t, J = 8.0 Hz, 1 H), 3.88 (s, 3H), 2.65 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.