Related Products of 447464-03-1, A common heterocyclic compound, 447464-03-1, name is 2-Fluoro-3-iodobenzoic acid, molecular formula is C7H4FIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0459] A solution of Example 73a (3.0 g, 11.2 mmol) and KBr03 (3.7 g, 22.0 mmol) in 15 mL of cone. H2S04. The reaction mixture was stirred for 2 h at 90C; LC-MS (BD01052-127) analysis showed Example 73a was consumed; the mixture was poured into 250 mL water and stirred for 10 min. The mixture was extracted with EA (250 mL * 3). The combined organic phase was dried over Na2S04, filtrated and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography to give the desired product (Example 73b, 3.5 g, yield: 65%) as a yellow solid.LCMS [M+l]+ = 344.0
The synthetic route of 447464-03-1 has been constantly updated, and we look forward to future research findings.