Reference of 42048-11-3,Some common heterocyclic compound, 42048-11-3, name is 2-Chloro-6-iodotoluene, molecular formula is C7H6ClI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 20a (5.0 g, 19.8 mmol) in CCL (50 mL) were added BPO (48.0 mg, 0.2 mmol) and NBS (3.52 g, 19.8 mmol) at room temperature. Tire resulting mixture was stirred at 90 C overnight, cooled to room temperature, concentrated. Tire residue was purified by silica gel chromatography column (PE) to afford 20b (3.0 g, 46%) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-6-iodotoluene, its application will become more common.