Related Products of 1000577-94-5, A common heterocyclic compound, 1000577-94-5, name is 3-Bromo-4-iodobenzonitrile, molecular formula is C7H3BrIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a nitrogen stream, in a 50 mL Schlenk tube,3.52 g (11.43 mmol) of 3-bromo-4-iodobenzonitrile, 6.35 g (28.58 mmol) of 9-phenanthreneboronic acid,51 mg (0.23 mmol),218 mg (0.46 mmol) of 2-dicyclohexylphosphino-2 ‘, 4′, 6’-triisopropylbiphenyl (Xphos), 15 mL of tetrahydrofuran,And 15 mL of 2 M potassium carbonate aqueous solution were added, and the mixture was stirred at 75 C. for 15 hours. After cooling to room temperature, methanol 100 mL was added and stirred, and the precipitated solid was collected by filtration and washed with pure water and methanol.By recrystallizing (chloroform / methanol) the residue,1.62 g (3.56 mmol) of a colorless powder of 9- [4-cyano-2- (9-phenanthryl) -phenyl] – phenanthrene was isolated (yield 31%, HPLC purity 98.4%).
The synthetic route of 1000577-94-5 has been constantly updated, and we look forward to future research findings.