These common heterocyclic compound, 74128-84-0, name is 2-Bromo-1-iodo-3-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Bromo-1-iodo-3-methoxybenzene
Under a nitrogen atmosphere, 31.3 g of 2-bromo-1-iodo-3-methoxybenzene,Phenyl dibenzo [b, d] furan-2-amine (26.0 g), A flask containing sodium-tert-butoxide (14.6 g) and toluene (200 ml) was heated to 90 C and bis [(tri-tertiary-butyl) phosphine] palladium (2.0 g) was added thereto. And refluxed under nitrogen for 24 hours.After cooling to room temperature, the mixture was filtered, and the solvent was distilled off under reduced pressure. The resulting solid was washed with acetonitrile to obtain 22.2 g of compound synthesis intermediate E
The synthetic route of 2-Bromo-1-iodo-3-methoxybenzene has been constantly updated, and we look forward to future research findings.