Electric Literature of 35453-19-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35453-19-1 name is 5-Amino-2,4,6-triiodoisophthalic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 1 Preparation of R iopamidol [R-5-(alpha-hydroxypropionylamino)-2,4,6-triiodoisophthalic add di-(1,3 dihydroxyisopropylamide)]. 400g (0.72 Mole) 5-amino-2,4,6-triiodoisophthalic acid should be added to 200 ml thionyl chloride, the mixture boiled and stirred for six hours, and the resulting solution then evaporated. The residue should then be dissolved in anhydrous ethyl acetate, and the solution should again be evaporated to dryness. The solid material should then be dissolved in 4000 ml ethyl acetate, and the solution stirred into an ice-cold solution of 500 g sodium chloride and 200 g sodium bicarbonate in 2.5 liters water. The organic phase should be separated from the aqueous solution, washed with aqueous sodium chloride solution, dried by contact with anhydrous calcium chloride, and evaporated to dryness. The resulting 5-amino-2,4,6-triiodoisophthalyl chloride has a melting point of about 300C when recrystallized from toluene.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-2,4,6-triiodoisophthalic acid, and friends who are interested can also refer to it.