Application of 624-75-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 624-75-9 name is 2-Iodoacetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
First, a stirrer was placed in a 35 mL sealed tube, and 35 muL of styrene (0.3 mmol), 1.0 ml of acetonitrile, and 44 muL of iodoacetonitrile (0.60 mmol) were added thereto, and 5·4 mg of Phen was added to the mixed solution. (0·03mmol), 5.7mgCul (0.03mmol) and 91yL DBU (0.60mmol), tightly seal the nozzle with a cock, heat to 110 C, stir for 1.5 hours, after the reaction is finished, the system is cooled to room temperature, into the reaction system 2 ml of distilled water was added, and the mixture was extracted with ethyl acetate. The organic phases were combined, and the solvent of the organic phase was evaporated under reduced pressure.36.5 mg of a colorless liquid product 3a was obtained by silica gel column chromatography, yield 85%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Iodoacetonitrile, and friends who are interested can also refer to it.