These common heterocyclic compound, 29289-13-2, name is 2-Iodo-4-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 29289-13-2
General procedure: A mixture of 2-iodoaniline (0.5 mmol), isothiocyanate (0.6 mmol), CuO nanoparticles (0.05 mmol), and Cs2CO3 (1.5 mmol) in PEG-400 (3mL) was stirred at 80C for 8h (Scheme 1). After the reaction, the reaction mixture was centrifuged and catalyst was separated from the reaction mixture and then followed by washing with ethyl acetate and acetone, dried in vacuo and used directly for further catalytic reactions. The cooled solution was partitioned between ethyl acetate and water, and the organic layer was washed with water and brine, and then dried over Na2SO4. After the removal of the solvent in vacuo, the residue was purified by silica-gel chromatography to give the desired N-substituted-2-aminobenzothiazoles. All the compounds were characterized by comparison with authentic samples [41].
The synthetic route of 2-Iodo-4-methylaniline has been constantly updated, and we look forward to future research findings.