Electric Literature of 52807-27-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52807-27-9, name is 4-Chloro-2-iodoanisole belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Under a nitrogen atmosphere, tris (dibenzylideneacetone) dipalladium (2.29 g, 2.5 mmol) , 1, V -bis (diphenylphosphi.no) ferrocene (2.11 g, 5 mmol) , sodium tert-butoxide (6.73 g, 70 mmol) and toluene (150 ml) were mixed. To this solution, 2-amino-3-bromo-5-methylpyridine (9.82 g, 52.5 mmol), 4-chloro-2-iodo-l-methoxybenzene (13.42 g, 50 mmol) and toluene (100 ml) were added. The mixture was stirred at an internal temperature of 9O0C for 2 hours. The reaction solution was cooled to room temperature, and IN hydrochloric acid (150 ml) was added thereto. The insoluble was filtered off and washed twice with toluene (50 ml) . The organic layer was separated and washed sequentially, once with 5N aqueous sodium hydroxide solution (50 ml) and twice with water (50 ml) . The organic layer was concentrated under reduced pressure, ethanol/acetone (4/1, 30 ml) was added to the concentrate, and the crystals were collected by filtration. The crystals were washed three times with ethanol/acetone (4/1, 15 ml) , and dried under reduced pressure at 50C, to yield the title compound (12.88 g) (yield 78.6%).1H-NMR (CDCl3, TMS, 300 MHz) delta (ppm) : 2.23 (3H, s) , 3.92 (3H, s), 6.77 (IH, d, J = 8.6 Hz), 6.87 (IH, dd, J = 2.5 Hz, 8.6 Hz), 7.59 (IH, d, J = 1.5 Hz), 7.75 (IH, brs) , 8.05 (IH, d, J = 1.0 Hz), 8.69 (IH, d, J = 2.5 Hz). 13C-NMR (CDCl3, TMS, 75 MHz) delta (ppm): 17.1, 56.2, 106.8, 110.4, 117.1, 120.1, 125.4, 126.0, 131.2, 140.9, 146.0, 146.3, 149.3.Mass analysis (Ci3Hi2N2OBrCl) Theoretical value: 326 Measured value: 327 [M+H]+Elemental analysis (Ci3Hi2N2OBrCl)Theoretical value: C, 47.66; H, 3.69; N, 8.55; Br, 24.39;
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-2-iodoanisole, other downstream synthetic routes, hurry up and to see.