Adding a certain compound to certain chemical reactions, such as: 6828-35-9, name is 5-Chloro-2-iodoaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6828-35-9, Recommanded Product: 6828-35-9
To a round-bottomed flask charged with 5-chloro-2-iodoaniline (1 g, 3.95 mmol, 1 equiv) was added a solution of 1:1 pyridine in CH2Cl2 (0.7 M, 40 mL) and the reaction mixture was cooled to 0 C. 4-Methylbenzenesulfonyl chloride (750 mg, 3.95 mmol, 1 equiv) was added portionwise, and the reaction mixture was allowed to slowly warm to room temperature and then stirred for 24 h. Upon completion of the reaction, water (80 mL) and CH2Cl2 (80 mL) were added. The reaction mixture was separated and the organics were washed with 1 N NaOH (2 × 40 mL), 1 N HCl (2×40 mL), and brine (2 × 40 mL). The organics were then passed through a hydrophobic frit and concentrated under reduced pressure to give a crude residue, which was purified by flash chromatography (silica gel, 0-12% EtOAc in petroleum ether) to afford the title compound as an off white solid (890 mg, 52%).1H NMR (CDCl3, 500 MHz): delta 7.72-7.65 (m, 3H), 7.57 (d, J = 8.5 Hz, 1H), 7.27 (d, J = 8.0 Hz, 2H), 6.88-6.80 (m, 2H), 2.42 (s, 3H).13C NMR (CDCl3, 126 MHz): delta 144.1, 139.1, 138.1, 135.1, 135.1, 129.4, 127.0, 126.4, 121.4, 88.3, 21.2. Characterisation data is consistent with literature reported values.4
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.