Electric Literature of 444-29-1, A common heterocyclic compound, 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, molecular formula is C7H4F3I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A Schlenk tube was charged with MCM-41-Sb,Py-CuI (122mg, 0.05mmol), triphenyphosphine (26mg, 0.10mmol), and K2CO3 (276mg, 2.0mmol). The tube was evacuated and backfilled with argon. Then, aryl halide (1.0mmol), terminal alkyne (1.2mmol) and DMF (4mL) were added under argon. The tube was sealed, and the reaction mixture was stirred at 100C for 6-24h. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (20mL), and filtered. The MCM-41-Sb,Py-CuI complex was washed with distilled water (2×5mL), DMF (2×5mL), and ethanol (2×5mL) and reused in the next run. The filtrate was washed with water, dried over MgSO4 and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel (petroleum/ethyl acetate=30:1-60:1) to provide the desired product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.