Electric Literature of 689260-53-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 689260-53-5 name is 2-Bromo-5-iodo-1,3-dimethylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To 2-Bromo-5-iodo-1,3-Dimethylbenzene(300 mg, 0.965 mmol),1-Amino cyclopropanecarboxylic acid(195 mg, 1.93 mmol),A mixture of copper (I) iodide (37 mg, 0.194 mmol) and diazabicycloundecene (0.50 ml, 3.35 mmol) in dimethylacetamide (2.6 ml) was heated at 120 C for 3 hours under a nitrogen stream Stirring. The reaction mixture was purified by silica gel column chromatography (Wakosil C18, acetonitrile-water (0.1% formic acid)1 – ((4-Bromo-3,5-Dimethylphenyl)Amino)Cyclopropanecarboxylic acid(219 mg, 80%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5-iodo-1,3-dimethylbenzene, and friends who are interested can also refer to it.