Some common heterocyclic compound, 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C14H18I3N3O6
In a three-necked flask equipped with a stirrer and a reflux condenser,5-amino-N, N’-bis- (2,3-dihydroxypropyl) -2,4,6-triiodo-1,3-benzenedicarboxamide (84.6 g, 0.12 mol)N, N-dimethylacetamide 172ml, stirred, heated to 50 C dissolved, cooled to 10 C, chloroacetyl chloride 62ml (88.09g, 0.78mol) dropwise over about 30min was completed, heated to 50 C and stirred for 3h, Cooled to 0 ~ 10 , at 10 ,156ml of 10mol / L sodium hydroxide solution was added dropwise and stirred at room temperature for 1h.100 ml of water was added and 59 ml of 1N hydrochloric acid was added dropwise. After standing overnight, the mixture was filtered and the filter cake was washed with water and dried to give 83.2 g. The yield was 90.0%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 76801-93-9, its application will become more common.