Adding a certain compound to certain chemical reactions, such as: 10297-05-9, name is 1-Chloro-4-iodobutane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10297-05-9, Recommanded Product: 10297-05-9
(Step 2) [1-(3-Hydroxypropyl)imidazolidin-2-ylidene] malononitrile (1.00 g, 5.21 mmol) obtained in the Step 1 was dissolved in DMF (10 mL) and the solution was sequentially added with potassium carbonate (1.44 g, 10.4 mmol) and 1-chloro-4-iodobutane (1.27 mL, 10.4 mmol). After stirring at room temperature for 18 hours, the mixture was added with saturated brine and extractd with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was washed with diisopropylether to obtain [1-(4-chlorobutyl)-3-(3-hydroxypropyl)imidazolidin-2-ylidene]malononitrile (1.35 g, 91.8percent) as a white solid. 1H NMR (CDCl3, deltappm): 1.80-2.00 (m, 6H), 3.53-3.78 (m, 12H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Chloro-4-iodobutane, and friends who are interested can also refer to it.