Reference of 461-17-6,Some common heterocyclic compound, 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, molecular formula is C4H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.4 g of 2- (2, 2,3, 3,4, 4,5, 5- octafluoropentyl) malononitrile and 1.2 g of 1-iodo-4, 4,4- trifluorobutane were dissolved in 5 ml of dimethyl sulfoxide, 0.83 g of potassium carbonate was added, and the mixture was stirred at room temperature for 5 hours. Thereafter, dilute hydrochloric acid was added to the reaction mixture, followed by extraction with methyl tert- butyl ether. The organic layer was washed successively with water, aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.35 g of 2- (2, 2,3, 3,4, 4,5, 5- octafluoropentyl)-2- (4, 4,4-trifluorobutyl) malononitrile (hereinafter, referred to as the present compound (66)). The present compound (66): lH-NMR (CDCl3, TMS) b (ppm): 2.01-2. 13 (2H, m), 2. 16-2. 32 (4H, m), 2.78 (2H, t), 6.02 (1H, tt).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-4-iodobutane, its application will become more common.