Application of 14452-30-3, A common heterocyclic compound, 14452-30-3, name is 1-(3-Iodophenyl)ethanone, molecular formula is C8H7IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Aryl halide (1 mmol), phenylacetylene (1.5 mmol), and PNIPAM-co-PPAP/Pd catalyst (0.1 mol% Pd based on Aryl halide) were added into a 10 mL overpressure screw-capped vial equipped with a magnetically stirring bar, and then 1 mL deionized water was added. After the mixture was degassed under argon gas for 10 min, Et3N (3 mmol) was added in, and the solution was stirred at a given temperature for appropriate time. After the reaction was completed and cooled to room temperature, the solution was diluted with deionized water, and extracted with ethyl acetate (3 × 6 mL). The organic phase was washed with brine, dried with MgSO4, and then the solvent was evaporated under reduced pressure. The resulting residue was chromatographed on silica gel (hexane/ethyl acetate) to give pure product which was analyzed by 1H and 13C NMR, and the specific data were shown in Supporting Information.
The synthetic route of 14452-30-3 has been constantly updated, and we look forward to future research findings.