Electric Literature of 627-32-7,Some common heterocyclic compound, 627-32-7, name is 3-Iodo-1-propanol, molecular formula is C3H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 33 2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-[1-(3-hydroxypropyl)-1H-pyrazol-3-yl]pyridine-3,5-dicarbonitrile 50 mg (0.092 mmol) of the compound from Example 5 were dissolved in 0.8 ml of DMF, 15 mg (0.101 mmol) of DBU and 21 mg (0.111 mmol) of 3-iodopropanol were added and the mixture was stirred at 120 C. overnight. A little water and ethyl acetate were added to the mixture, and the two phases formed were separated. The aqueous phase was extracted twice with ethyl acetate. The combined organic phases were concentrated on a rotary evaporator and the residue was purified by thick-layer chromatography (toluene:acetonitrile=3:1). Yield: 18 mg (38% of theory) 1H-NMR (400 MHz, DMSO-d6): delta=8.10 (br s, 2H), 7.96-7.90 (m, 4H), 7.57 (d, 2H), 6.74 (d, 1H), 4.62 (s, 2H), 4.60 (t, 1H), 4.26 (t, 2H), 3.40 (q, 2H), 1.96 (Quintett, 2H). LC-MS (Method 2): Rt=2.54 min; MS (ESIpos): m/z=508 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Iodo-1-propanol, its application will become more common.