Related Products of 1320266-94-1,Some common heterocyclic compound, 1320266-94-1, name is 1-Iodo-3-isopropylimidazo[1,5-a]pyrazin-8-amine, molecular formula is C9H11IN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N-(4-(8-amino-3-isopropylimidazo[l,5-a]pyrazin-l-yl)naphthalen-l-yl)-3- (trifluoromethyl)benzamide (GP146(Am)). A mixture of compound 1 (9.5 mg, 0.031 mmol), compound 4 (16.6 mg, 0.038 mmol), Tetrakis(triphenylphosphine)palladium (1.1 mg, 0.94 muetaiotaomicron) and sodium carbonate (7.3 mg, 0.069 mmol) was dissolved in a 3: 1 mixture of DME/water (120 muEpsilon). The mixture was heated overnight at 85 C. The crude mixture was cooled to room temperature, diluted in a mixture of acetonitrile/water and purified by reverse phase chromatography (HPLC) to obtain 5.3 mg of GP146(Am) (34% yield). TLC (CH2C12:MeOH, 95:5 v/v): Rf = 0.5; 1H NMR (300 MHz, MeOD) delta 8.46 (s, 1H), 8.42 (d, J = 6.0 Hz, 2H), 8.16- 8.13 (m, 1H), 8.01-7.98 (m, 1H), 7.86-7.84 (m, 1H), 7.81-7.77 (m, 2H), 7.72-7.69 (m, 1H), 7.68 – 7.62 (m, 2H), 7.60-7.54 (m, 1H), 7.06 (d, J = 6.0 Hz, 1H), 3.61 – 3.52 (m, 1H), 1.53 – 1.46 (m, 6H); ESI-MS (m/z): [M]+ calcd. for C27H22F3N50, 489.18; [M+l]+ found, 490.4 The purity of GP146(Am) was determined to be >98% by analytical HPLC.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Iodo-3-isopropylimidazo[1,5-a]pyrazin-8-amine, its application will become more common.