These common heterocyclic compound, 25252-00-0, name is 2-Bromo-5-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Bromo-5-iodobenzoic acid
2-Bromo-5-iodobenzoic acid 5a (40.0 g, 122 mmol) was dissolved in dichloromethane (350 mL)Then, it was cooled to -5 C under a nitrogen atmosphere, and oxalyl chloride (16.4 mL, 194 mmol) was added dropwise.After reacting with N,N-dimethylformamide (1.5 mL, 19 mmol), the mixture was stirred at room temperature for 4 hours.After the reaction is completed, the organic solvent is removed by concentration under reduced pressure.The title compound 5b (46.0 g, yellow solid)Yield: 100%.
The synthetic route of 2-Bromo-5-iodobenzoic acid has been constantly updated, and we look forward to future research findings.