Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, A new synthetic method of this compound is introduced below., name: 1,1,1-Trifluoro-4-iodobutane
2-(2,4-Dichlorophenyl)-5-methyl-1-[4-(4,4,4-trifluorobutoxy)-phenyl]-1H-imidazole-4-carboxylic acid piperidin-1-ylamide l-Iodo-4, 4,4-trifluorobutane (376 mg, 1.58 mmol) was added dropwise to a suspension of 2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-1H-imidazole-4-carboxylic acid piperidin-1-ylamide, from Ex 2, Step 1 (351 mg, 0.79 mmol) and K2CO3 (218 mg, 1.58 mmol) in 50 ml acetone. The reaction mixture was refluxed overnight, cooled, filtered and concentrated. Flash chromatography (silica, hexane: EtOAc 1: 2) afforded 200 mg (46%) of the title compound as a white solid. ‘H NMR (CDC13) : 8 8. 0 (1H, broad s), 7.4-7. 2 (3H, m), 7.1-7. 0 (2H, m), 6.9-6. 8 (2H, m), 4.1-4. 0 (2H, m), 3.0-2. 9 (4H, m), 2.5-2. 2 (5H, m), 2.2-2. 0 (2H, m), 1.9-1. 7 (4H, m), 1.6-1. 4 (2H, m). MS m/z 578 (M+Na). HPLC: 99.4%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.