Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 619-58-9, name is 4-Iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Iodobenzoic acid
To a solution of 4-iodobenzoic acid (2.0g, 1.0mmol), copper (I) iodide (1.7g, 1.13mmol), palladium chloride (0.02g, 0.15mmol) and triphenylphosphine (2.1g, 1.0mmol) in triethylamine (7ml), was added ethynyltrimethylsilane (1.2g, 1.5mmol) dropwise over 30min. The resulting reaction mixture was then refluxed at 80C for 24h under an atmosphere of argon and monitored by TLC. After the completion of reaction, as indicated by the complete disappearance of starting material on TLC, the mixture was cooled and filtered through a Buchner funnel. The volatile solvents were removed under reduced pressure. The resulting crude light brown coloured material was extracted into ether, washed with brine solution, dried over anhydrous sodium sulphate, and concentrated. Finally the silylated product was purified by column chromatography on silica gel with 3% ethyl acetate in hexane as an eluent yielding 86% of pure 4-[2-(trimethylsilyl)ethynyl]benzoic acid (2). Off white solid, 1.53g; IR: 2953, 2156, 1681, 1604, 1454, 1377, 1251, 858cm-1; 1H NMR (500MHz, CDCl3): 8.0 (d, J=8.6, 2H, Ar-H), 7.6 (d, J=8.4, 2H, Ar-H), 0.27 (s, 9H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 619-58-9.