Application of 628-77-3, These common heterocyclic compound, 628-77-3, name is 1,5-Diiodopentane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The [Reaction Scheme 1-5 obtained [Intermediate 1-e] 9.7 g in the reactor 300 mL (21 mmol), into a tetrahydrofuran 77 mL, was cooled to 0 . In potassium-tert-butoxide 7.1 g (63 mmol) slowly and stir. 10 minutes later, it was added dropwise a solution of 1,5-diiodopentane 10.3 g (32 mmol) in 10 mL tetrahydrofuran at 0 , and the temperature was raised to room temperature and stirred for 24 hours. Into water, then the organic layer was extracted and then concentrated under reduced pressure, the resulting solid was purified by recrystallization to obtain the compound [formula 2] 4.7 g (yield: 42.2%)
The synthetic route of 628-77-3 has been constantly updated, and we look forward to future research findings.