Electric Literature of 1643-29-4,Some common heterocyclic compound, 1643-29-4, name is 3-(4-Iodophenyl)propanoic acid, molecular formula is C9H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-(4-iodophenyl)propanoic acid (Atlantic Research Chemicals Ltd.) (2.76 g, 10.00 mmol) were dissolved In tetrahydrofuran (100 mL) and added slowly to a suspension of lithium aluminium hydride (0.23 g, 6.00 mmol) in 100 mL tetrahydrofuran. The reaction was stirred for 3h, then 1 N aqueous sodium hydrogen carbonate (150 mL) were added slowly and the resulting mixture was extracted with ethyl acetate (3 x 400 mL), the organic extracts were dried over magnesium sulfate and concentrated in vacuo. The crude product was purified on silica gel using a hexane/ethyl acetate gradient, and the appropriate fractions were combined and concentrated. Yield: 1.30 g (49.8%) 1H-NMR (300MHz, CHLOROFORM-d): delta [ppm]= 1.88 (m, 2H), 2.62 – 2.72 (m, 2H), 3.64 – 3.70 (m, 2H), 6.97 (d, 2H), 7.61 (d, 2H). ESI+ m/z 263.2 (M+H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(4-Iodophenyl)propanoic acid, its application will become more common.