Reference of 461-17-6,Some common heterocyclic compound, 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, molecular formula is C4H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
l-(2,4-Dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-lH-pyrazole-3-carboxylic acid piperidin-l-yl amide from 1, Step F (250 mg, 0.56 mmol) was dissolved in acetone (10 ml) and potassium carbonate (77 mg, 0.56 mmol) was added followed by l-iodo-4,4,4- trifluorobutane (140 mg, 0.56 mmol). The reaction mixture was boiled under reflux overnight, concentrated and purified by flash chromatography (hexane : EtOAc 70 : 30 – 60 : 40) afforded 130 mg (42%) of a white solid that was triturated with hexane : EtOAc 95 : 5 and filtered.1H NMR(CDCl3): 5 7.63 (IH, broad s), 7.43 (IH, m), 7.30 (2H, m), 7.10-7.00 (2H, m), 6.85-6.78 (2H, m), 4.05 (2H, t), 2.90 (4H, m), 2.40-2.19 (5H, s and m), 2.15-1.97 (2H, m), 1.78 (4H, m), 1.45 (2 H, m). MS m/z 577 (M+Na). HPLC: 98.4%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-4-iodobutane, its application will become more common.