Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148870-57-9, name is 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C15H18INO3
Example 11Charge 21.0 g of [N-[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-l,3,5-trien-7-yl]methyl]-N- methylamine (V), 43.15 g of 3-(3-iodopropyl)-7,8-dimethoxy-l,3-dihydro-2H-3- benzazepine-2-one (XII), 60.0 g of K2CO3 and 315 ml of DMF in a RB flask equipped with mechanical stirrer and thermometer pocket at 25C. Heat the reaction mixture to 40-450C and maintain at the same temperature for 12 hours. Monitor the reaction by HPLC. (if starting material i.e. compound (V) remains, add compound (XII) and continue heating with stirring till compound (V) comes to less than 1.0%). If HPLC complies, cool the reaction mixture to 25C. Charge 1500 ml of IN HCl (pH should be acidic), 1500 ml of ethyl acetate (3 x 500 ml) and stir for 10 minutes and separate the layers. Charge 10% NaOH solution to aqueous layer till pH of the solution becomes basic (pH ~ 7.0 – 8.0). Charge ethyacetate (2 x 500.0 ml), stir for 10 minutes and separate the layers. Wash the ethyl acetate layer with 500 ml of water. Dry ethyl acetate layer over anhydrous Na2SO4 and evaporate ethyl acetate under vacuum at below 50C to result a brown colored residue (XIII). Weight: 43.0 gYield: 91.0 %HPLC purity (Reverse phase): >98.5%
According to the analysis of related databases, 148870-57-9, the application of this compound in the production field has become more and more popular.