New learning discoveries about 2-(3-Iodophenyl)acetic acid

The synthetic route of 1878-69-9 has been constantly updated, and we look forward to future research findings.

1878-69-9, name is 2-(3-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H7IO2

To a solution of 3-iodorhohenylacetic acid (24.8 g, 94.6 mmol) in CH2Cl2 (200 mL) was added oxalyl chloride (189 mmol, 2 equiv), followed by a drop of DMF. The mixture was stirred at room temperature for Ih and then concentrated. Addition of ethanol and purification by flash chromatography (EtOAc/Hex) gave yellow oil as product. 1H NMR (600 MHz, CDCl3): delta = 7.63 (s, 1 H), 7.59 (d, 1 H), 7.25 (d, 1 H), 7.04 (t, 1 H), 4.16 (q, 2 H), 3.53 (s, 2 H), 1.25 (t, 3 H); LRMS: m+1 (291.0, 4.228 min.).

The synthetic route of 1878-69-9 has been constantly updated, and we look forward to future research findings.