Adding a certain compound to certain chemical reactions, such as: 620-05-3, name is (Iodomethyl)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 620-05-3, category: iodides-buliding-blocks
General procedure: A solution of iodomethyl compound (30 mmol) and ionic liquid [bmpy]PF6 (15 mL) was taken in a round bottom flask, and then H5IO6 (36 mmol) and V2O5 (0.9 mmol) were added to reaction solution at r.t. Reaction content was heated at 70 C with continuous stirring for about 4-9 h. Reaction progress was monitored by means of TLC using EtOAc/n-hexane 1:9 as an eluent. After completion of reaction, the product was extracted with DCM (3 × 10 mL). The organic layer was isolated and washed with 5% NaHCO3 solution (3 × 10 mL) and water (3 × 10 mL) to make the pH neutral. Then, the organic layer was dried over Na2SO4 and filtered. The carbonyl compound was purified through recrystallization from hexane and ethyl acetate (solid product) or by distillation (liquid product). In some cases, column chromatography was required to purify product. In these cases, the solvent was removed followed by column chromatography using hexane/ethyl acetate (8:1) as eluent which afforded carbonyl compound (83-94%). The rest of the ionic liquid and the catalyst were recovered by decantation of aqueous hydrogen halide produced in the reaction and concentrated under vacuum. Fresh substrates were then recharged to the recovered catalytic system and then recycled under specified reaction parameters.
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