Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82998-57-0, name is 3-Iodo-4-methylbenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Iodo-4-methylbenzoic acid
To the flask was added 250 ml of thionyl chloride and 26.2 g of 3-iodo-4-methylbenzoic acid, stirred and heated under reflux for 6 h,After drying under reduced pressure, dry dichloroethane was added and the solvent was removed under reduced pressure.Followed by adding 250 ml of chloroform, 20 ml of diisopropylethylamine,A solution of 24.1 g of 3- (4-methylimidazol-1-yl) -5-trifluoromethylaniline, and the temperature was raised to 60 C for 5 h.After completion of the reaction, the solvent was concentrated under reduced pressure to remove the solvent. Add ethyl acetateEster 200ml dissolved, washed 3 times, dried and concentrated, the resulting solid separation by column chromatography, eluentDichloromethane / methanol = 9, the desired fractions were collected and concentrated to give 28 g of a solid in 57% yield.
According to the analysis of related databases, 82998-57-0, the application of this compound in the production field has become more and more popular.